Salvage radiotherapy after radical prostatectomy: outcomes and prognostic factors especially focusing on pathological findings

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Salvage radiotherapy after radical prostatectomy: outcomes and prognostic factors especially focusing on pathological findings

External beam radiotherapy is a potential salvage or adjuvant therapy after radical prostatectomy (RP). The purpose of this study was to investigate the treatment outcome of salvage radiotherapy (RT) following RP for clinically localized prostate cancer and to identify factors that may predict the outcome of salvage RT. Between 2000 and 2006, 41 patients received salvage RT because of increasin...

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Salvage radical prostatectomy after radiotherapy.

OBJECTIVES To determine the oncological and functional results obtained after salvage radical prostatectomy (SRP) in patients with recurrence following radiotherapy (3 consecutive PSA rises after a nadir until the year 2006, then 2 ng/mL above nadir ) for prostate cancer (PC), and to analyze the impact of different pre-and postoperative variables on biochemical recurrence-free survival (BCR-fre...

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Adjuvant and salvage radiotherapy after radical prostatectomy.

BACKGROUND Following radical prostatectomy, between 15 and 60% of all patients with pT3 prostate cancer experience persistence or increasing levels of prostate-specific antigen (PSA) as a sign of tumor persistence or progression within 5 years. Retrospective studies have shown a rate of 35-55% of positive biopsies from the vesicourethral anastomosis in this situation. Best treatment for these d...

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Salvage Radiotherapy after Radical Prostatectomy: Prediction of Biochemical Outcomes

INTRODUCTION A significant proportion of patients undergoing salvage radiotherapy (RT) for biochemical recurrence (BCR) following radical prostatectomy (RP) may again experience BCR after salvage RT. Thus, we evaluated the clinical significances of different parameters on the biochemical outcome of RT in salvage setting. METHODS We reviewed the records of 212 patients who underwent salvage RT...

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Salvage radiotherapy following radical prostatectomy.

Recurrent disease following radical prostatectomy will occur in approximately 20% of patients, for whom the therapeutic options include surveillance, salvage radiotherapy, or hormonal therapy. This review will focus on the evidence for salvage radiotherapy. Efficacy results of 30-50% have been reported from multiple retrospective series, with minimal morbidity. Unfortunately there are no random...

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ژورنال

عنوان ژورنال: Journal of Radiation Research

سال: 2012

ISSN: 0449-3060,1349-9157

DOI: 10.1093/jrr/rrs034